Project 1: Elucidating Mechanisms of Viral-Induced Mitochondria Injury

My research laboratory is interested in the intricate dynamics between cardiotropic viruses and mitochondrial dysfunction in the heart. Through investigating the interactions between specific viral proteins and mitochondrial host factors, we aim to better understand and address the mitochondrial damage these viruses cause. Ultimately, our goal is to pinpoint innovative mitochondrial-based therapeutic strategies for treating viral heart failure, pushing beyond the limitations of current treatments that mainly tackle symptoms without resolving the core issues.

Project 2: Characterizing the pathological role of complement activation during viral infection

My research group seeks to understand the newly discovered link between cardiovascular diseases of viral etiology and the complement pathway, typically associated with antibacterial defense. We are particularly focused on the effects of CVB3 infection on complement protective factors on cell membranes. A crucial component of our research is evaluating the potential of complement blockade, such as with the use of specific anti-complement

Project 3: Mapping the genetic risk factors of viral heart disease in diverse populations

In alignment with the emphasis on personalized medicine, our team aims to decode the genetic factors predisposing individuals to virus-induced heart failure. In collaboration with Canada-based and international biobanks, we intend to sequence biobanked cardiac tissues of viral etiology to identify specific genetic vulnerabilities tied to mitochondrial biology and complement activation. This could herald a new era of tailored and more effective treatment strategies for at risk individuals and populations.