2023
Engineering a facile and versatile nanoplatform to facilitate the delivery of multiple agents for targeted breast cancer chemo-immunotherapy A Bahreyni, Y Mohamud, J Zhang, H Luo
Biomedicine & Pharmacotherapy 163, 114789
A combination of genetically engineered oncolytic virus and melittin-CpG for cancer viro-chemo-immunotherapy
A Bahreyni, H Liu, Y Mohamud, YC Xue, YM Fan, YL Zhang, H Luo
BMC medicine 21 (1), 193
Recent advancements in immunotherapy of melanoma using nanotechnology-based strategies
A Bahreyni, Y Mohamud, H Luo
Biomedicine & Pharmacotherapy 159, 114243
Mitochondria Dysfunction at the Heart of Viral Myocarditis: Mechanistic Insights and Therapeutic Implications
Y Mohamud, B Li, A Bahreyni, H Luo
Viruses 15 (2), 351
Cleavage of 14-3-3e by the enteroviral 3C protease dampens RIG-I mediated antiviral signaling
DD Andrews, Y Mohamud, M Vlok, DA Bani, BN Hay, LJ Foster, H Luo, …
Journal of Virology
2022
Enhanced genomic stability of new miRNA-regulated oncolytic coxsackievirus B3
H Liu, A Bahreyni, Y Mohamud, YC Xue, WWG Jia, H Luo
Molecular Therapy-Oncolytics 27, 89-99
A new miRNA-Modified coxsackievirus B3 inhibits triple negative breast cancer growth with improved safety profile in immunocompetent mice
A Bahreyni, H Liu, Y Mohamud, YC Xue, J Zhang, H Luo
Cancer Letters 548, 215849
Viral proteases activate the CARD8 inflammasome in the human cardiovascular system
R Nadkarni, WC Chu, CQE Lee, Y Mohamud, L Yap, GA Toh, S Beh, …
Journal of Experimental Medicine 219 (10), e20212117
Coxsackievirus Protease 2A Targets Host Protease ATG4A to Impair Autophagy
YM Fan, YL Zhang, A Bahreyni, H Luo, Y Mohamud
Viruses 14 (9), 2026
Crosstalk between RNA viruses and DNA sensors: Role of the cGAS-STING signalling pathway
YM Fan, YL Zhang, H Luo, Y Mohamud
Reviews in Medical Virology, e2343
Sublethal enteroviral infection exacerbates disease progression in an ALS mouse model
YC Xue, H Liu, Y Mohamud, A Bahreyni, J Zhang, NR Cashman, H Luo
Journal of neuroinflammation 19 (1), 1-15
2021
Coxsackievirus B3 targets TFEB to disrupt lysosomal function
Y Mohamud, H Tang, YC Xue, H Liu, CS Ng, A Bahreyni, H Luo
Autophagy 17 (12), 3924-3938
Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome
I Pablos, Y Machado, HCR de Jesus, Y Mohamud, R Kappelhoff, …
Cell reports 37 (4)
SNAP47 Interacts with ATG14 to Promote VP1 Conjugation and CVB3 Propagation
P Xiang&, Y Mohamud&, H Luo (& authors contributed equally)
Cells 10 (8), 2141
Autophagy receptor protein Tax1-binding protein 1/TRAF6-binding protein is a cellular substrate of enteroviral proteinase
Y Mohamud, YC Xue, H Liu, CS Ng, A Bahreyni, H Luo
Frontiers in Microbiology 12, 647410
FUS/TLS suppresses enterovirus replication and promotes antiviral innate immune responses
YC Xue, CS Ng, Y Mohamud, G Fung, H Liu, A Bahreyni, J Zhang, H Luo
Journal of Virology 95 (12), 10.1128/jvi. 00304-21
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, …
Autophagy 17 (1), 1-382
Coxsackievirus B3 subversion of the autophagy pathway
Y Mohamud
University of British Columbia
2020
Emerging nanomedicines for effective breast cancer immunotherapy
A Bahreyni, Y Mohamud, H Luo
Journal of nanobiotechnology 18 (1), 1-14
Coxsackievirus infection induces a non-canonical autophagy independent of the ULK and PI3K complexes
Y Mohamud, J Shi, H Tang, P Xiang, YC Xue, H Liu, CS Ng, H Luo
Scientific Reports 10 (1), 19068
Dysregulation of RNA-binding proteins in amyotrophic lateral sclerosis
YC Xue, CS Ng, P Xiang, H Liu, K Zhang, Y Mohamud, H Luo
Frontiers in molecular neuroscience 13, 78
MicroRNA modification of coxsackievirus B3 decreases its toxicity, while retaining oncolytic potency against lung cancer
H Liu, YC Xue, H Deng, Y Mohamud, CS Ng, A Chu, CJ Lim, …
Molecular Therapy-Oncolytics 16, 207-218
The papain-like protease of coronaviruses cleaves ULK1 to disrupt host autophagy
Y Mohamud, YC Xue, H Liu, CS Ng, A Bahreyni, E Jan, H Luo
Biochemical and Biophysical Research Communications
2019
Coxsackievirus type B3 is a potent oncolytic virus against KRAS-mutant lung adenocarcinoma
H Deng, H Liu, T de Silva, YC Xue, Y Mohamud, CS Ng, J Qu, J Zhang, …
Molecular Therapy-Oncolytics 14, 266-278
CALCOCO2/NDP52 and SQSTM1/p62 differentially regulate coxsackievirus B3 propagation
Y Mohamud, J Qu, YC Xue, H Liu, H Deng, H Luo
Cell Death & Differentiation 26 (6), 1062-1076
The intertwined life cycles of enterovirus and autophagy
Y Mohamud, H Luo
Virulence 10 (1), 470-480
NLRP3 deficiency exacerbates enterovirus infection in mice
C Wang, G Fung, H Deng, J Jagdeo, Y Mohamud, YC Xue, E Jan, …
The FASEB Journal 33 (1), 942-952
2018
Enteroviral infection leads to transactive response DNA-binding protein 43 pathology in vivo
YC Xue, CM Ruller, G Fung, Y Mohamud, H Deng, H Liu, J Zhang, …
The American journal of pathology 188 (12), 2853-2862
Oh, SNAP! How enteroviruses redirect autophagic traffic away from degradation
AK Corona#, Y Mohamud#, WT Jackson, H Luo (# authors contributed equally)
Autophagy 14 (8), 1469-1471
Enteroviral infection inhibits autophagic flux via disruption of the SNARE complex to enhance viral replication
Y Mohamud, J Shi, J Qu, T Poon, YC Xue, H Deng, J Zhang, H Luo
Cell reports 22 (12), 3292-3303
2017
Phosphorylation and degradation of aB-crystallin during enterovirus infection facilitates viral replication and induces viral pathogenesis
G Fung, J Wong, F Berhe, Y Mohamud, YC Xue, H Luo
Oncotarget 8 (43), 74767
Coxsackievirus type B3 is a potent oncolytic virus against KRAS-mutant non-small cell lung cancer
H Deng, TD Sliva, Y Xue, Y Mohamud, J Zhang, W Lockwood, H Luo
Annals of Oncology 28, ii47-ii48
2015
The Role of PJA2-CDK5R1 in ß-cell Function
Y Mohamud
Université d’Ottawa/University of Ottawa
Viral Frontiers Laboratory 